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REDOSTIM®

40 tabs of 520 mg

Original price was: 26,00 €.Current price is: 23,00 €. excl. VAT

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For HIM & HER | Gluten & Lactose Free | Vegan-Friendly

REDOSTIM® is a patented micronutrients combination containing supra-physiologic amounts of activated vitamin B6 (pyridoxal 5-phosphate – P5P) together with L-cystine (that is 2 cysteines) and taurine. In its active form, P5P, Vitamin B6 supports the activity of several thousands of enzymes including those responsible for the synthesis of cysteine, the substrate for the release of the universal antioxidant GSH, and of hydrogen sulphide (H2S), a gaseous signalling molecule provided with strong antioxidant activity. Cysteine is the substrate for the generation of both GSH and H2S while taurine contributes to keep high cellular cysteines. H2S is the latest discovered among gasotransmitters. It is involved in the regulation of redox metabolism, immune homeostasis, endothelial function and chronic inflammation. H2S is a main regulator of the reproductive process, from gametogenesis to delivery, and its progressive decline is considered a marker of the aging process.
 
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Background health modulator

Master regulator of reproduction and pregnancy and of a healthy aging

 

✔️ Vitamin B6 availability and inflammation

Vitamin B6 occurs in food in various forms (vitamers) and is activated within cells to pyridoxal 5-phosphate (P5P). It has been observed since long time that P5P levels sharply decrease during acute inflammation with less evident changes in chronic inflammation. The likely reason is that in inflamed tissues there is an increased inactivation of P5P due to oxidation and de-phosphorylation by inflammation-induced enzymes, mainly alkaline phosphatase. As a matter of fact, inflammatory processes “consume” active B6 and generate an increased demand.

 

✔️ Vitamin B6 availability and H2S release

The main enzymes releasing GSH and H2S are vitamin B6 dose-dependent, i.e. the more the B6, the more the activity. While normally using homocysteine to produce cysteine that feeds GSH release, at higher P5P concentration the same enzymes change their activity to use both homocysteine and cysteine to generate H2S.

 

✔️ A smart metabolic regulator

The combined effect of L-cystine, taurine and supraphysiological doses of B6/P5P is an increase in the synthesis of glutathione (GSH) and hydrogen sulfide (H2S). However, H2S will be released only where and when it is needed in response to the regulating mechanisms. In other words, Redostim’s combination of micronutrients has the ability to make cells more responsive to H2S release signals but will not produce any release in the absence of such signals.

 

✔️ Gasotransmitters: hidden regulators of physiology

H2S is the third discovered gasotransmitter, after nitric oxide (NO) and carbon monoxide (CO). They are vanishing gases that escaped for long time our observation and that are now the major challenge in the metabolism research. The gases can be produced by every cell and diffuse to other cells and to the bloodstream and then disappear very fast. Anytime the gases are released thousands of proteins/enzymes change their activity. They produce deep effects and modulate every physiologic function.

 

✔️ H2S in the reproductive process

H2S is increasingly released throughout the reproductive process. It is released by the testes and by maturing ovarian follicles, thereafter by the corpus luteum and by the placenta, to sharply drop at time of labour. During follicular development H2S induces immunotolerant changes in the endometrium that will have to accept a semi-allogenic fetus (entirely allogenic in case of oocyte donation), which is the very first barrier to the implantation. It also inhibits the uterine contractions to avoid the expulsion of the embryo. At the same time H2S stimulates the vascularization of the endometrium to ensure adequate blood flow throughout the pregnancy. At term, the sharp drop of H2S removes the inhibition to uterine motility and triggers the labour.

 

✔️ H2S and progesterone

Many of the above actions are known to result from progesterone, indeed the hormone effects are largely mediated by the induction of H2S. Should this induction fail for any reasons, there would be no progesterone effects downstream. This may explain why some women experience lack of immune tolerance and/or of endometrial vascularization, leading to implantation failure, even if progesterone levels are high and why further increasing progesterone (luteal support) in these women produces little effects. The same may apply to other complications of pregnancy such as hypertension and preeclampsia.

 

✔️ H2S and menstrual pain

We have seen that at the end of pregnancy it is the rapid fall in the release of H2S that triggers uterine contractions and labor. In the menstrual cycle the same thing happens on a smaller scale: At mid cycle, in the absence of fertilization, the release of H2S stops triggering, also in this case, uterine contractions in order to expel the detaching mucosa (menstruation). In some women the drop in H2S can be excessive and, therefore, the equally excessive uterine contractions generate intense pain.
A positive effect of B6 on menstrual pain had been noted since the 1980s and many naturopaths actually prescribe it. In reality, the effect on H2S of standard B6 (pyridoxine) and without cystine and taurine is modest while the complete Redostim formula has a well-documented efficiency in supporting the release of H2S.

 

✔️ H2S, chronic inflammation and endothelial dysfunction

Endothelia are the cell layers lining the inner surface of blood vessels and playing as the main regulator of vasodilation, of platelets and coagulation and of molecular exchanges with the tissues. Chronic inflammation of the endothelia hampers these functions, which is called endothelial dysfunction, and is a main trigger of atherosclerosis. H2S is directly involved in all these functions and acts as a vasodilator and as inhibitor of platelet aggregation and coagulation. More important, H2S prevents the inflammation of the endothelia by keeping circulating lymphocytes at rest, i.e. does not allow them to attach to the endothelium, which would trigger the release of inflammatory cytokines.

 

✔️ H2S and aging

Our ability to release H2S progressively decline during aging. On the other side, the aging process is in substance the progressive deterioration of all the functions sustained by H2S. This raises the hypothesis that keeping adequate levels of H2S may delay the aging process and prolong the healthy phase of life. Based on animal models, the only so far validated intervention that expands the life span is caloric restriction and most of the humans enjoying very long life are have been conservative eaters during their life. Many of the effects of caloric restriction are mediated by the onset of a H2S-centred metabolism and the same happens in hibernating animals during their resting period.

 

✔️ The hybrid engine of mammalian cells

Our cells need energy to live and the energy demand is extremely high in some cells like neurons and sperms. They produce the energy they need in the form of ATP by burning fatty acids and glucose in mitochondria. A compulsory side effect of this energy production is the release of reactive oxygen species (ROS) proportionally to the amount of ATP generated. Thus, cells with intensive need for ATP, e.g. sperms, produce large amounts of ROS that may eventually damage the swimming function and the integrity of DNA, e.g. DNA fragmentation in sperms. However, our cells possess the ability to shift to another energy substrate, H2S. The gas enters the respiratory chain downstream to the site of release of ROS and triggers the production of discrete amounts of ATP without adding oxidative aggression, which is a kind of “clean energy”. This is indeed the mechanism in place in caloric restriction and in hibernation. The same processes may be of great relevance in improving the bioenergetics while reducing the oxidative load in energy demanding cells, including sperms.

 

Weight 0,057 kg
Dimensions 10,5 × 7 × 2 cm
Gross Weight

36 g

Net Weight

20,8 g

Package Content

40 non-filmed tablets of 520 mg into two blisters of 20 tablets each. There is no leaflet inside. The product comes with Italian box.

Intake, Doses & Warnings

▶ Take one tablet 2 times a day (2 tabs) or more to be swallowed with water, preferably between meals. Do not exceed the recommended dose.
▶ Keep out of the reach of children under three years of age.
▶ Do not administer to children under three years of age.
▶ Do not take in case of known or suspected allergy to one or more of the ingredients. Please check the composition first.

Composition

Ingredients 2 tab %NVR – Nutritional Value Reference
L-Cystine 250 mg  
L-Taurine 250 mg  
Vitamin B6 (Pyridoxal-5-Phosphate) 10 mg 714%

Distributors

  BOSNIA-HERZEGOVINA

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  GERMANY

TRAIECTUM HEALTHCARE

C/ FRANZISKA BEYER HENDRICHPLATZ 13 10367 BERLIN GERMANY

impryl.de

IMPRYL®

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  GREECE

PARTHENOGENESIS HELLAS

YMITTOU 225, ATHINA 11326, GREECE

parthenogenesis.gr

IMPRYL®

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  IRELAND

HEALTH MEDICA LTD

4-6 COLONIAL BUSINESS PARK, COLONIAL WAY, WATFORD, HERTFORDSHIRE, WD24 4PR. UK

fertilityfamily.co.uk

IMPRYL®

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  ITALY

PARTHENOGEN EUROPE ITALIA

VIALE VITTORIO VENETO 23, 21020 VARANO BORGHI, ITALY

ita.parthenogen.eu

IMPRYL®

REDOSTIM®

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  KOSOVO

PARTOGEN İLAÇ

BALMUMCU MAHALLESI, ITRI SK, NO:14,34349 BEŞIKTAŞ / İSTANBUL, TURKEY

partogen.com.tr

IMPRYL®

REDOSTIM®

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  MONTENEGRO

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  NETHERLAND

GOODLIFE PHARMA B.V.

NAARDERPOORT 2B 1411 MA NAARDEN NEDERLAND

goodlifepharma.com

IMPRYL®

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  MACEDONIA

SVN D.O.O.

ANKARSKA 23 LOK.7 SKOPJE NORTH MACEDONIA

svn.com.mk

IMPRYL®

REDOSTIM®

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  SERBIA

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  SWITZERLAND

PARTHENOGEN SUISSE

PIAZZA INDIPENDENZA 11, 6900 LUGANO, SWITZERLAND

suisse.parthenogen.ch

IMPRYL®

REDOSTIM®

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  TURKEY

PARTOGEN İLAÇ

BALMUMCU MAHALLESI, ITRI SK, NO:14,34349 BEŞIKTAŞ / İSTANBUL, TURKEY

partogen.com.tr

IMPRYL®

REDOSTIM®

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  UKRAINE

RC PHARMA

01042, KIEV, STR. MARIA PRYIMACHENKO 1/27, UKRAINE

rcpharma.com.ua

IMPRYL®

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  UNITED KINGDOM

HEALTH MEDICA LTD

4-6 COLONIAL BUSINESS PARK, COLONIAL WAY, WATFORD, HERTFORDSHIRE, WD24 4PR. UK

fertilityfamily.co.uk

IMPRYL®

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  USA

GRAIL VENTURES LLC

1000 N. WEST STREET, STE. 1200, WILMINGTON, DE 19801

imprylusa.com

IMPRYL®

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  VIETNAM

THIENNAM PHARMA

20/28/72 Duong HO DAC DI, Phuong TAY THANH, Quan TAN PHU, Thanh pho HO CHI MINH, VIETNAM

thiennampharma.com

IMPRYL®

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F.A.Q.

REDOSTIM® –  Frequently Asked Questions

What is REDOSTIM®?

Redostim is a patented, non-GMO, gluten-free, vegan-friendly dietary supplement that delivers essential micronutrients that stimulate the endogenous production of H2S, the latest discovered among gasotransmitters that is involved in the regulation of redox metabolism, immune homeostasis, endothelial function and chronic inflammation.

What are the ingredients in REDOSTIM®?

Redostim is a patented micronutrients combination containing supra-physiologic amounts of activated vitamin B6 (pyridoxal 5-phosphate – P5P) together with L-cystine (that is 2 cysteines) and taurine.

How is REDOSTIM® supplied?

Carton box. Each box of Redostim contains 40 non-filmed tablets of 520 mg.

Who should take REDOSTIM®?

Redostim is formulated for adults (age 18 years and older); it should not be consumed by children.

How should REDOSTIM® be taken?

Two (or more) tablets of Redostim should be taken each day (twice a day) with a full glass of water between meals. Ideally, Redostim should be taken at approximately the same time each day.

How long should REDOSTIM® be taken?

If possible, both women and men should take Redostim for at least 90 days to take its effects properly.

How should REDOSTIM® be stored?

Redostim should be stored in its original packaging at room temperature out of the reach of children. It should be protected from direct sunlight, as well as extreme oscillations in temperature and/or humidity.

How does REDOSTIM® works?

Redostim ingredients were carefully selected because each plays an important role in a process in your body. In its active form, P5P, Vitamin B6 supports the activity of several thousands of enzymes including those responsible for the synthesis of cysteine, the substrate for the release of the universal antioxidant GSH, and of hydrogen sulphide (H2S), a gaseous signalling molecule provided with strong antioxidant activity. Cysteine is the substrate for the generation of both GSH and H2S while taurine contributes to keep high cellular cysteines. Learn more about how Redostim works.

What is Hydrogen Sulphide (H2S)?

H2S is the latest discovered among gasotransmitters. It is involved in the regulation of redox metabolism, immune homeostasis, endothelial function and chronic inflammation.

Why is Hydrogen Sulphide (H2S) important?

H2S is a main regulator of the reproductive process, from gametogenesis to delivery, and its progressive decline is considered a marker of the aging process. Learn about how Redostim works.

What is a methyl group?

A methyl group is a single carbon atom bonded with three hydrogen atoms. The methionine pathway of One Carbon Metabolism (OCM) produces S-adenosylmethionine (SAMe), one of the most important activated methyl donor in the human body. Methyl groups can be dynamically transferred to and from biological macromolecules such as DNA, RNA and proteins in a process called methylation to influence their functional output.

What is homocysteine (HCY)?

Homocysteine is a naturally occurring, non-proteinogenic amino acid that accumulates when One Carbon Metabolism (OCM) is suboptimal. Elevated levels of homocysteine are a risk factor for multiple human reproductive health issues, including both male and female infertility, preeclampsia, miscarriage, and birth defects like spina bifida. Homocysteine is recycled to methionine through methylation by the methionine and betaine pathway of OCM, or converted to cystathione by the transsulfuration pathway of OCM.

What is glutathione?

Glutathione is the most important naturally occurring antioxidant in the human body. It can block oxidative damage to important biological macromolecules caused by reactive oxygen species (ROS), including free radicals, peroxides, lipid peroxides and heavy metals. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM). Glutathione, and the natural antioxidant activity it provides, is important for your fertility.

What is gene expression?

Gene expression is the process by which a sequence of DNA becomes a “gene product”, more commonly known as a protein. The ability to make proteins at specific times and places in the body is essential for normal development, and leads to individualized traits like hair color. Expression of genes can be regulated in several ways, including epigenetics, a process by which environmental factors, age and lifestyle choices can alter which genes are made into proteins without actually altering the DNA sequence. One well-known example of this phenomenon is a process called methylation, which is the transfer of methyl groups to DNA or histone proteins to alter gene expression. Epigenetic mechanisms play important roles in virtually all cell types, including male sperm and female eggs.

What is the importance of 5-MTHF and Methylcobalamin?

5-MTHF and methylcobalamin assure that the re-methylation of homocysteine to methionine can still occur (and prevent homocysteine accumulation) in the presence of genetic variants of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), respectively. In the presence of normal MTHFR and MTRR genes, the activated vitamins represent additional donor molecules for One Carbon Metabolism (OCM).

What is the importance of L-Cystine and Betaine?

L-cystine is a precursor of cysteine, one of the three components of glutathione, and a determinant of the rate of synthesis of this critical antioxidant in the transsulfuration pathway of One Carbon Metabolism (OCM). L-cystine can therefore serve as a precursor of cysteine to facilitate glutathione synthesis in the presence of cystathionine beta-synthase (CBS) genetic variants. Betaine (also called trimethyl-glycine) is produced in the body from choline. While choline does play other roles in the body, the production of betaine is essential because it serves as a methyl donor in the methionine pathway of OCM to promote re-methylation of homocysteine to methionine.

What is the importance of Vitamin B2, B3, B6 and zinc?

Vitamin B2, B3, B6 and zinc are all necessary cofactors for the critical enzymes in One Carbon Metabolism (OCM).

What is the consequence of genetic variants?

Mutations in MTHFR and MTRR may lead to elevated levels of homocysteine, which is a risk factor for myriad human health issues, including both male and female infertility, preeclampsia, miscarriage, cardiovascular disease, neuropsychiatric illness, and fracture. Mutations in CBS may lead to reduced levels of the vital antioxidant glutathione; this can alter the intracellular redox balance and contribute to the oxidation of important biological macromolecules.

How is REDOSTIM® manufactured?

Redostim is manufactured in the Italy using domestic and imported ingredients in a facility that is certified to current good manufacturing practice (cGMP) standards. Following manufacturing, each lot of Redostim is laboratory tested and released for sale only after demonstrating compliance with product-specific acceptance criteria.

Is REDOSTIM® Gluten-Free?

Yes, Redostim is gluten-free.

Is REDOSTIM® Lactose-Free?

Yes, Redostim is lactose-free.

Is REDOSTIM® suitable for use by vegetarians and vegans?

Yes, Redostim can be used by individuals who consciously choose to avoid products of animal origin. In addition, none of the ingredients in Redostim are produced using genetically modified organisms (GMO).

Does REDOSTIM® contain any artificial colors or flavors?

No, Redostim does not contain any artificial colors or flavors.

Does REDOSTIM® have any side effects?

Redostim contains ingredients that are both present in the food supply and naturally occur in the body, at concentrations that approximate the recommended daily allowances. Nevertheless, adults consuming Redostim should consult a physician if pregnant or nursing, taking prescription medication, or have a medical condition, and Redostim should never be consumed by individuals with known allergies to any ingredients in the product.

Can REDOSTIM® packaging be recycled?

Redostim packaging are composed by a carton box (PAP21) and 2 blisters (C/PVC). Please check the regulations of your country.

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  1. The Best!

  2. Great

  3. Sperăm la o evoluție bună

  4. Very good company

  5. Danke

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Q & A

Hi, i am34 years old, i have Endometriosis caused low egg quality and from surgeries i have low AMH 0.4. I I took impryal for 7 months now early morning on empty stomach. I want to add Redostim before i start my IVF cycle next month. Would please advise me for the best time to take both. Thank you. Azeeza Almenhali asked on February 14, 2024

Dear Customer, thank you for your enquiry. Our medical department will contact you for due discussion.

Parthenogen Europe Team

Parthenogen Europe answered on February 15, 2024 store manager
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Redostim box 30 tabs, enREDOSTIM®
Original price was: 26,00 €.Current price is: 23,00 €. excl. VAT
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