IMPRYL®

Impryl is a patented, non-GMO, gluten-free, vegan-friendly dietary supplement that delivers essential micronutrients when you are trying to have a baby. These micronutrients support a biochemical process called One-Carbon Metabolism (OCM) that is important for the reproductive health and fertility of both women and men.

Impryl contains riboflavin (Vitamin B2), niacin (Vitamin B3), pyridoxine (Vitamin B6), 5-methyltetrahydrofolate (activated Vitamin B9), methylcobalamin (activated Vitamin B12), zinc, betaine and L-cystine. These ingredients are either essential (must be consumed in the diet) or semi-essential (can be made in the body, but typically not in sufficient quantities) and several are in their activated forms (don’t require processing by the body).
In addition, Impryl contains the inactive ingredients microcrystaline cellulose, mono- and diglycerides of fatty acids, Magnesium salts of fatty acids, silicon dioxide and cross-linked sodium carboxy methyl cellulose. These substances are mandatory to keep stable the nutrients.

Carton box. Each box of Impryl contains 30 non-filmed tablets of 1300 mg. You can split the tablets into smaller pieces to make them easier to swallow.

Impryl is formulated for adults (age 18 years and older); it should not be consumed by children below 3. However, lactating mothers may take IMpryl and deliver the support via maternal milk.
Impryl is intended for preconception supplementation of the diet in both women and men desiring to conceive naturally or through an assisted reproductive technology (ART) cycle, including ovulation induction, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Although Impryl does not contain a full prenatal support, it can be taken during pregnancy, which may benefit intrauterine growth.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.

One tablet of Impryl should be taken each day with a full glass of water between meals. Ideally, Impryl should be taken at approximately the same time each day.

Impryl is a dietary integration and just like any other meal, the benefits immediately starts at assumption and stop at withdrawal with a minimal remnant effect. However, the longer the treatment, the larger the benefits.
For reproductive purposes, both women and men should take Impryl for at least 90 days prior to natural conception or an ART procedure, and then until a pregnancy is achieved. This duration is based on the duration of folliculogenesis/ovulation (egg production) and spermatogenesis (sperm production). However, if it is not possible to take Impryl for 90 days or longer, any shorter duration will be of benefit. The assumption may be continued during pregnancy and lactation.
Those willing to control their homocysteine should be aware that the feeding effects, as well those on homocysteine, will terminate days to weeks after withdrawal and homocysteine may raise back to pre-treatment values.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.

Impryl should be stored in its original packaging at room temperature out of the reach of children. It should be protected from direct sunlight, as well as extreme oscillations in temperature and/or humidity.

Impryl ingredients were carefully selected because each plays an important role in a process in your body called One Carbon Metabolism (OCM). OCM uses the micronutrients provided by Impryl to power five biological processes – homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression – each important for sperm health and egg quality, fertilization, and the growth and development of the baby.

OCM is a network of biochemical cycles (folate and methionine) and biochemical pathways (betaine and transsulfuration) that involve the transfer of a single carbon molecule in the form of a methyl, methylene or formyl group from one molecule to another. OCM has been shown to be critical for the reproductive health of women and men.

OCM is important because it functionally connects the dietary intake of micronutrients with critical biological processes, including homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression. Learn about how Impryl works. Disruption of OCM by diet, environmental exposure or genetic variations is associated with multiple human reproductive health problems, including reduced sperm health and egg quality, infertility and miscarriage, as well as birth defects, including spina bifida.

A methyl group is a single carbon atom bonded with three hydrogen atoms. The methionine pathway of One Carbon Metabolism (OCM) produces S-adenosylmethionine (SAMe), the universal activated methyl donor in the human body. Methyl groups can be dynamically transferred to and from biological macromolecules such as DNA, RNA and proteins in a process called methylation to influence structure and function.

Homocysteine is a naturally occurring, non-proteinogenic amino acid that accumulates when One Carbon Metabolism (OCM) is suboptimal. Elevated levels of homocysteine are a risk factor for multiple human reproductive health issues, including both male and female infertility, preeclampsia, miscarriage, and birth defects like spina bifida. Homocysteine is recycled to methionine through methylation by the methionine and betaine pathway of OCM, or converted to cystathione by the transsulfuration pathway of OCM.

Glutathione (GSH) is the main antioxidant in the human body. It diffuses everywhere and continuously re-charges with antioxidant power all the other physiologic antioxidants. Important, GSH is not a dietary substance and is not provided by the diet neither can be assumed as a supplement. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM) using homocysteine/cysteine as the main substrate.

5-MTHF and methylcobalamin are methyl donors necessary for the re-methylation of homocysteine to methionine. Carriers of defective genetic variants of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), are weak producers of, respectively, 5-MTHF and methylcobalamin and may be at risk of shortage of these substances.

Betaine (also called trimethyl-glycine) is produced in the body from choline. While choline does play other roles in the body, the production of betaine is essential because it serves as a methyl donor in the methionine pathway of OCM to promote re-methylation of homocysteine to methionine.

L-cystine is made of two cysteines and is the soluble and circulating form of cysteine. Into the cells, L-cystine is transformd into 2 cysteines on demand. Cysteine is the main substrate for the synthesis of the main physiologic antioxidants: glutathione (GSH) and of hydrogen sulfide (H₂S).

Vitamin B2, B3 and B6 are all necessary cofactors for the critical enzymes in One Carbon Metabolism (OCM).

Zinc is a metal that binds certain enzymes and essential for their activity. Only zinc bound to dietary proteins or to other carrier molecules can be adsorbed can, in Impryl the carrier is bisglycinate. Rather, elemental zinc as contained by many supplements is completely lost with the feces.
All the 3 main enzymes eliminating homocysteine to form methionine or cysteine are zinc-dependent and the OCM cannot work properly if any shortage of zinc is in place. Thus, it is very important for the effects of Impryl.
However, zinc competes with other bivalent metals, mainly copper and magnesium, for transport into the cells. Therefore, excessive supplementation of zinc leading to high concentration, may reduce the transport and availability of other cations with negative consequences. This is the reason why, a few years ago, Parthenogen decreased the amount of zinc per tablet from 15 to 10 mg. Always updated with any new findings, we deserve further reductions of zinc amounts should the data advice so.

Genetic variants are genetic traits that are different from the most common ones (called wild type) but occurring with high frequency (> 10%) and are therefore physiologic. In other words, they are not diseases, they are just “variants” from normal. In some cases the variant generates an enzyme with a decreased activity, likely because it was (and is) and advantage in certain situations. In the case of MTHFR variants, resulting in decreased output of 5MTHF, one may argue that it was an advantage against malaria (shorter half life of red cells) and is an advantage against cancers (that are usually folate dependent). The same may apply to the majority of genetic variants, the larger their frequency, the more the side benefits they bring.
However, it may happen that multiple genetic variants on the same pathway converge on the same subject generating a critical assembly. In these cases any increased demand or toxic load may generate a metabolic collapse. Such collapse is predicted to occur at time of increased demand, which in the case of the one carbon metabolism is at time to reproduce.

Impryl is manufactured in the Italy using domestic and imported ingredients in a facility that is certified to current good manufacturing practice (cGMP) standards. Following manufacturing, each lot of Impryl is laboratory tested and released for sale only after demonstrating compliance with product-specific acceptance criteria.

Yes, Impryl is gluten-free.

Yes, Impryl is lactose-free.

Yes, Impryl can be used by individuals who consciously choose to avoid products of animal origin. In addition, none of the ingredients in Impryl are produced using genetically modified organisms (GMO).

No, Impryl does not contain any artificial colors or flavors.

Impryl contains ingredients that are both present in the food supply and naturally occur in the body, at concentrations that approximate the recommended daily allowances. Nevertheless, adults consuming Impryl should consult a physician if pregnant or nursing, taking prescription medication, or have a medical condition, and Impryl should never be consumed by individuals with known allergies to any ingredients in the product.

Impryl packaging are composed by a carton box (PAP21) and 2 blisters (C/PVC). Please check the regulations of your country.