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IMPRYL®

30 tabs of 1300 mg

Original price was: 48,00 €.Current price is: 35,00 €. excl. VAT

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For HIM & HER | Gluten & Lactose Free | Vegan-Friendly

IMPRYL® is the antioxidant support with methylfolate and methylcobalamin to restore redox balance, energy production and cell viability for the health of the embryo and of the pregnancy and for a controlled ageing. Several ingredients of IMPRYL® are provided in their already activated form, i.e. downstream to possible genetic weakness of the concerned metabolic enzymes, so to ensure full coverage to everybody independently of their background genetics. The combined effect of its micronutrients is a boost to methylations, which are necessary for key biochemical syntheses including DNA, RNA and key substances like CoQ10 and carnitine and for the process of DNA methylation as part of the epigenetic programming. The increased methylations also result in a strong boost to the endogenous release of glutathione (GSH), a key physiologic antioxidant.

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Supplement of health for all ages

Contributes to the growth of gametes, embryos, fetuses and infants and to metabolic and redox balance in adults

 

✔️ Activated micronutrients

We were not born all the same. The evolution ensured to humans wide genetic variability so that our genes, and our proteins/enzymes coded by such genes, carry little differences each other. These differences, called genetic variants, are very common among genes/proteins/enzymes involved in the metabolism of key dietary substances, mainly in the one carbon metabolism. Impryl is a unique (patented, indeed) micronutrient combination where the main dietary substances are provided in a pre-activated form so that, whatever your background genetics, their supportive effect will remain the same.

 

✔️ Synergic effects of micronutrients

The micronutrients of Impryl, besides providing physiologic substrates for biochemical processes, also deliver regulatory signals to our metabolism generating a virtuous circle. The methyl donors (methylfolate, methylcobalamin, betaine) increase the methylation capacity for efficient tissue development and epigenetics while also giving green light to the production of antioxidant power. On the other hand, the antioxidant activity, which is directly supported by B6 and cysteines, activate the generation of methylations. The final effect is the activation of both processes at a level that would not be possible by acting on any of the two single pathways.

 

✔️ Endogenous antioxidant activity

Impryl does not deliver any antioxidant substances, rather it delivers the substrates and signals to activate the endogenous generation of antioxidant power in the form of GSH. Thereafter, GSH will be re-charging all the other antioxidant substances, which is its physiologic role. However, it is only a permissive action, it will be the regulation of cell homeostasis to decide if antioxidant activity is needed, where, and how much. Thus, the boost to GSH generation will be of unparalleled efficiency if there is a true shortage of antioxidant power whereas it will be a mild action if the need is not in place or already satisfied. In other words, there is no risk of excessive antioxidant power and of reductive stress.

 

✔️ For HIM and HER

From a genetic point of view a male is a female missing a small part of the “X” chromosome so that it takes the shape and the name of “Y” chromosome. The main effect of this deletion is an androgenic imbalance in males, however all the mechanisms downstream to the hormones are exactly the same in both sexes. To simplify, the male and female metabolism are precisely the same and leverage on the same dietary substances and on the same biochemistry.
Accordingly, and even more as far as gametogenesis is concerned, speaking of “male” opposed to “female” supplements is a non-sense. To make an example, methylations are very relevant in spermatogenesis to achieve a final compaction (protection) of the sperm DNA whereas in oocytes the same processes work to create a methylation reserve to be used after fertilization in the early embryo: Nevertheless, they use the same substrates and the same enzymes under the same regulatory mechanisms and within the same time period (gametogenesis). How could the dietary requirements be different? Would you accept the idea that a pregnancy of a male foetus should be supported differently from a pregnancy of a female foetus?
Any time they offer you male and female versions of a supplement they are joking with you, we do not.

 

✔️ Quality beyond labels

Impryl, just like any other Parthenogen’s product, is manufactured according to good manufacturing practices at plants regularly inspected by Health Authorities. In-process controls ensure that the manufacturing is always within the needed standards at any point of manufacturing. At the end of the process, each batch is analysed to confirm that it is within the specifications before it is released to the market. Finally, samples from manufactured batches are kept at different type of stressing conditions to ensure that the content of the product survives to the stress, and how long, which is called stability programs. In order to achieve such stability, i.e. to avoid reactions among the nutrients leading to different (reduced) final contents, we have to add pharmaceutical excipients. In the case of Impryl, containing 8 different hydro-soluble nutrients for a total of 430 mg of actives, to achieve stability over time we must add 870 mg of excipients leading to a tablet of 1300 mg.

 

Weight 0,057 kg
Dimensions 7 × 2 × 13 cm
Gross Weight

57 g

Net Weight

39 g

Package Contents

30 non-filmed tablets of 1300 mg into two blisters of 15 tablets each. There is no leaflet inside. The product comes with Italian box.

Intake, Doses & Warnings

IMPRYL box is a 1-month treatment:
▶ Take one (1x) tablet a day to be swallowed with water, preferably between meals. You can split the tablets into smaller pieces to make them easier to swallow. Do not exceed the recommended dose.
▶ Keep out of the reach of children under three years of age.
▶ Do not administer to children under three years of age.
▶ Do not take in case of known or suspected allergy to one or more of the ingredients. Please check the composition first.

Composition

Ingredients 1 tab %NVR – Nutritional Value Reference
Betaine 200 mg  
L-Cystine 200 mg  
Zinc 10 mg 100%
Niacin 16 mg 100%
Vitamin B6 1,4 mg 100%
Riboflavin 1,4 mg 100%
Folic Acid (5MTHF) 400 µg 200%
Vitamin B12 (Methylcobalamin) 2,5 µg 100%

Distributors

  BOSNIA-HERZEGOVINA

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  GERMANY

TRAIECTUM HEALTHCARE

C/ FRANZISKA BEYER HENDRICHPLATZ 13 10367 BERLIN GERMANY

impryl.de

IMPRYL®

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  GREECE

PARTHENOGENESIS HELLAS

YMITTOU 225, ATHINA 11326, GREECE

parthenogenesis.gr

IMPRYL®

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  IRELAND

HEALTH MEDICA LTD

4-6 COLONIAL BUSINESS PARK, COLONIAL WAY, WATFORD, HERTFORDSHIRE, WD24 4PR. UK

fertilityfamily.co.uk

IMPRYL®

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  ITALY

PARTHENOGEN EUROPE ITALIA

VIALE VITTORIO VENETO 23, 21020 VARANO BORGHI, ITALY

ita.parthenogen.eu

IMPRYL®

REDOSTIM®

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  KOSOVO

PARTOGEN İLAÇ

BALMUMCU MAHALLESI, ITRI SK, NO:14,34349 BEŞIKTAŞ / İSTANBUL, TURKEY

partogen.com.tr

IMPRYL®

REDOSTIM®

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  MONTENEGRO

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  NETHERLAND

GOODLIFE PHARMA B.V.

NAARDERPOORT 2B 1411 MA NAARDEN NEDERLAND

goodlifepharma.com

IMPRYL®

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  MACEDONIA

SVN D.O.O.

ANKARSKA 23 LOK.7 SKOPJE NORTH MACEDONIA

svn.com.mk

IMPRYL®

REDOSTIM®

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  SERBIA

VITROMEDIC D.O.O.

MIHAILA ŠUŠKALOVIĆA 13 11147 BELGRADE SERBIA

vitromedic.com

IMPRYL®

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  SWITZERLAND

PARTHENOGEN SUISSE

PIAZZA INDIPENDENZA 11, 6900 LUGANO, SWITZERLAND

suisse.parthenogen.ch

IMPRYL®

REDOSTIM®

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  TURKEY

PARTOGEN İLAÇ

BALMUMCU MAHALLESI, ITRI SK, NO:14,34349 BEŞIKTAŞ / İSTANBUL, TURKEY

partogen.com.tr

IMPRYL®

REDOSTIM®

Are you a distributor and want to become our partner? Contact us!

  UKRAINE

RC PHARMA

01042, KIEV, STR. MARIA PRYIMACHENKO 1/27, UKRAINE

rcpharma.com.ua

IMPRYL®

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  UNITED KINGDOM

HEALTH MEDICA LTD

4-6 COLONIAL BUSINESS PARK, COLONIAL WAY, WATFORD, HERTFORDSHIRE, WD24 4PR. UK

fertilityfamily.co.uk

IMPRYL®

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  USA

GRAIL VENTURES LLC

1000 N. WEST STREET, STE. 1200, WILMINGTON, DE 19801

imprylusa.com

IMPRYL®

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  VIETNAM

THIENNAM PHARMA

20/28/72 Duong HO DAC DI, Phuong TAY THANH, Quan TAN PHU, Thanh pho HO CHI MINH, VIETNAM

thiennampharma.com

IMPRYL®

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F.A.Q.

IMPRYL® –  Frequently Asked Questions

What is IMPRYL®?

Impryl is a patented, non-GMO, gluten-free, vegan-friendly dietary supplement that delivers essential micronutrients when you are trying to have a baby. These micronutrients support a biochemical process called One-Carbon Metabolism (OCM) that is important for the reproductive health and fertility of both women and men.

What are the ingredients in IMPRYL®?

Impryl contains riboflavin (Vitamin B2), niacin (Vitamin B3), pyridoxine (Vitamin B6), 5-methyltetrahydrofolate (activated Vitamin B9), methylcobalamin (activated Vitamin B12), zinc, betaine and L-cystine. These ingredients are either essential (must be consumed in the diet) or semi-essential (can be made in the body, but typically not in sufficient quantities) and several are in their activated forms (don’t require processing by the body).
In addition, Impryl contains the inactive ingredients microcrystaline cellulose, mono- and diglycerides of fatty acids, Magnesium salts of fatty acids, silicon dioxide and cross-linked sodium carboxy methyl cellulose. These substances are mandatory to keep stable the nutrients.

How is IMPRYL® supplied?

Carton box. Each box of Impryl contains 30 non-filmed tablets of 1300 mg. You can split the tablets into smaller pieces to make them easier to swallow.

Who should take IMPRYL®?

Impryl is formulated for adults (age 18 years and older); it should not be consumed by children below 3. However, lactating mothers may take IMpryl and deliver the support via maternal milk.
Impryl is intended for preconception supplementation of the diet in both women and men desiring to conceive naturally or through an assisted reproductive technology (ART) cycle, including ovulation induction, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Although Impryl does not contain a full prenatal support, it can be taken during pregnancy, which may benefit intrauterine growth.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.

How should IMPRYL® be taken?

One tablet of Impryl should be taken each day with a full glass of water between meals. Ideally, Impryl should be taken at approximately the same time each day.

How long should IMPRYL® be taken?

Impryl is a dietary integration and just like any other meal, the benefits immediately starts at assumption and stop at withdrawal with a minimal remnant effect. However, the longer the treatment, the larger the benefits.
For reproductive purposes, both women and men should take Impryl for at least 90 days prior to natural conception or an ART procedure, and then until a pregnancy is achieved. This duration is based on the duration of folliculogenesis/ovulation (egg production) and spermatogenesis (sperm production). However, if it is not possible to take Impryl for 90 days or longer, any shorter duration will be of benefit. The assumption may be continued during pregnancy and lactation.
Those willing to control their homocysteine should be aware that the feeding effects, as well those on homocysteine, will terminate days to weeks after withdrawal and homocysteine may raise back to pre-treatment values.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.

How should IMPRYL® be stored?

Impryl should be stored in its original packaging at room temperature out of the reach of children. It should be protected from direct sunlight, as well as extreme oscillations in temperature and/or humidity.

How does IMPRYL® works?

Impryl ingredients were carefully selected because each plays an important role in a process in your body called One Carbon Metabolism (OCM). OCM uses the micronutrients provided by Impryl to power five biological processes – homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression – each important for sperm health and egg quality, fertilization, and the growth and development of the baby.

What is One Carbon Metabolism (OCM)?

OCM is a network of biochemical cycles (folate and methionine) and biochemical pathways (betaine and transsulfuration) that involve the transfer of a single carbon molecule in the form of a methyl, methylene or formyl group from one molecule to another. OCM has been shown to be critical for the reproductive health of women and men.

Why is One Carbon Metabolism (OCM) important?

OCM is important because it functionally connects the dietary intake of micronutrients with critical biological processes, including homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression. Learn about how Impryl works. Disruption of OCM by diet, environmental exposure or genetic variations is associated with multiple human reproductive health problems, including reduced sperm health and egg quality, infertility and miscarriage, as well as birth defects, including spina bifida.

What is a methyl group?

A methyl group is a single carbon atom bonded with three hydrogen atoms. The methionine pathway of One Carbon Metabolism (OCM) produces S-adenosylmethionine (SAMe), the universal activated methyl donor in the human body. Methyl groups can be dynamically transferred to and from biological macromolecules such as DNA, RNA and proteins in a process called methylation to influence structure and function.

What is homocysteine (HCY)?

Homocysteine is a naturally occurring, non-proteinogenic amino acid that accumulates when One Carbon Metabolism (OCM) is suboptimal. Elevated levels of homocysteine are a risk factor for multiple human reproductive health issues, including both male and female infertility, preeclampsia, miscarriage, and birth defects like spina bifida. Homocysteine is recycled to methionine through methylation by the methionine and betaine pathway of OCM, or converted to cystathione by the transsulfuration pathway of OCM.

What is glutathione?

Glutathione (GSH) is the main antioxidant in the human body. It diffuses everywhere and continuously re-charges with antioxidant power all the other physiologic antioxidants. Important, GSH is not a dietary substance and is not provided by the diet neither can be assumed as a supplement. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM) using homocysteine/cysteine as the main substrate.

What is the importance of 5-MTHF and Methylcobalamin?

5-MTHF and methylcobalamin are methyl donors necessary for the re-methylation of homocysteine to methionine. Carriers of defective genetic variants of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), are weak producers of, respectively, 5-MTHF and methylcobalamin and may be at risk of shortage of these substances.

What is the importance of Betaine?

Betaine (also called trimethyl-glycine) is produced in the body from choline. While choline does play other roles in the body, the production of betaine is essential because it serves as a methyl donor in the methionine pathway of OCM to promote re-methylation of homocysteine to methionine.

What is the importance of L-Cystine?

L-cystine is made of two cysteines and is the soluble and circulating form of cysteine. Into the cells, L-cystine is transformd into 2 cysteines on demand. Cysteine is the main substrate for the synthesis of the main physiologic antioxidants: glutathione (GSH) and of hydrogen sulfide (H2S).

What is the importance of Vitamin B2, B3 and B6?

Vitamin B2, B3 and B6 are all necessary cofactors for the critical enzymes in One Carbon Metabolism (OCM).

What is the importance of zinc?

Zinc is a metal that binds certain enzymes and essential for their activity. Only zinc bound to dietary proteins or to other carrier molecules can be adsorbed can, in Impryl the carrier is bisglycinate. Rather, elemental zinc as contained by many supplements is completely lost with the feces.
All the 3 main enzymes eliminating homocysteine to form methionine or cysteine are zinc-dependent and the OCM cannot work properly if any shortage of zinc is in place. Thus, it is very important for the effects of Impryl.
However, zinc competes with other bivalent metals, mainly copper and magnesium, for transport into the cells. Therefore, excessive supplementation of zinc leading to high concentration, may reduce the transport and availability of other cations with negative consequences. This is the reason why, a few years ago, Parthenogen decreased the amount of zinc per tablet from 15 to 10 mg. Always updated with any new findings, we deserve further reductions of zinc amounts should the data advice so.

What is the consequence of genetic variants?

Genetic variants are genetic traits that are different from the most common ones (called wild type) but occurring with high frequency (> 10%) and are therefore physiologic. In other words, they are not diseases, they are just “variants” from normal. In some cases the variant generates an enzyme with a decreased activity, likely because it was (and is) and advantage in certain situations. In the case of MTHFR variants, resulting in decreased output of 5MTHF, one may argue that it was an advantage against malaria (shorter half life of red cells) and is an advantage against cancers (that are usually folate dependent). The same may apply to the majority of genetic variants, the larger their frequency, the more the side benefits they bring.
However, it may happen that multiple genetic variants on the same pathway converge on the same subject generating a critical assembly. In these cases any increased demand or toxic load may generate a metabolic collapse. Such collapse is predicted to occur at time of increased demand, which in the case of the one carbon metabolism is at time to reproduce.

How is IMPRYL® manufactured?

Impryl is manufactured in the Italy using domestic and imported ingredients in a facility that is certified to current good manufacturing practice (cGMP) standards. Following manufacturing, each lot of Impryl is laboratory tested and released for sale only after demonstrating compliance with product-specific acceptance criteria.

Is IMPRYL® Gluten-Free?

Yes, Impryl is gluten-free.

Is IMPRYL® Lactose-Free?

Yes, Impryl is lactose-free.

Is IMPRYL® suitable for use by vegetarians and vegans?

Yes, Impryl can be used by individuals who consciously choose to avoid products of animal origin. In addition, none of the ingredients in Impryl are produced using genetically modified organisms (GMO).

Does IMPRYL® contain any artificial colors or flavors?

No, Impryl does not contain any artificial colors or flavors.

Does IMPRYL® have any side effects?

Impryl contains ingredients that are both present in the food supply and naturally occur in the body, at concentrations that approximate the recommended daily allowances. Nevertheless, adults consuming Impryl should consult a physician if pregnant or nursing, taking prescription medication, or have a medical condition, and Impryl should never be consumed by individuals with known allergies to any ingredients in the product.

Can IMPRYL® packaging be recycled?

Impryl packaging are composed by a carton box (PAP21) and 2 blisters (C/PVC). Please check the regulations of your country.

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5.0
Based on 72 reviews
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  1. very good

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Q & A

What is the form of B6 that you use in Impryl? Anna asked on April 25, 2024

Dear Customer,

Thank you for your question. The form of B6 in Impryl® is Pyridoxine HCL.

With regards,
Parthenogen Europe

Parthenogen Europe answered on April 25, 2024 store manager
(0) (0)
For shipping un Romania, in how many days will be delivered? Mehmet Georgiana-Laura asked on November 15, 2023

Dear Customer,

Depending on your delivery address, every shipment may take 1-3 working days to be delivered.
For more information on our policies, please refer to our terms and conditions: https://eusales.parthenogen.eu/terms-and-conditions/

If you have any further questions or concerns, please don't hesitate to ask. We're always happy to help.

Parthenogen Europe Team

Parthenogen Europe answered on November 15, 2023 store manager
(0) (0)

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IMPRYL® Methylfolate for the health of gametes, embryos and pregnancies - box 30 tabs, en .IMPRYL®
Original price was: 48,00 €.Current price is: 35,00 €. excl. VAT
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