What is IMPRYL®?
Impryl is a patented, non-GMO, gluten-free, vegan-friendly dietary supplement that delivers essential micronutrients when you are trying to have a baby. These micronutrients support a biochemical process called One-Carbon Metabolism (OCM) that is important for the reproductive health and fertility of both women and men.
What are the ingredients in IMPRYL®?
Impryl contains riboflavin (Vitamin B2), niacin (Vitamin B3), pyridoxine (Vitamin B6), 5-methyltetrahydrofolate (activated Vitamin B9), methylcobalamin (activated Vitamin B12), zinc, betaine and L-cystine. These ingredients are either essential (must be consumed in the diet) or semi-essential (can be made in the body, but typically not in sufficient quantities) and several are in their activated forms (don’t require processing by the body).
In addition, Impryl contains the inactive ingredients microcrystaline cellulose, mono- and diglycerides of fatty acids, Magnesium salts of fatty acids, silicon dioxide and cross-linked sodium carboxy methyl cellulose. These substances are mandatory to keep stable the nutrients.
How is IMPRYL® supplied?
Carton box. Each box of Impryl contains 30 non-filmed tablets of 1300 mg. You can split the tablets into smaller pieces to make them easier to swallow.
Who should take IMPRYL®?
Impryl is formulated for adults (age 18 years and older); it should not be consumed by children below 3. However, lactating mothers may take IMpryl and deliver the support via maternal milk.
Impryl is intended for preconception supplementation of the diet in both women and men desiring to conceive naturally or through an assisted reproductive technology (ART) cycle, including ovulation induction, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Although Impryl does not contain a full prenatal support, it can be taken during pregnancy, which may benefit intrauterine growth.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.
How should IMPRYL® be taken?
One tablet of Impryl should be taken each day with a full glass of water between meals. Ideally, Impryl should be taken at approximately the same time each day.
How long should IMPRYL® be taken?
Impryl is a dietary integration and just like any other meal, the benefits immediately starts at assumption and stop at withdrawal with a minimal remnant effect. However, the longer the treatment, the larger the benefits.
For reproductive purposes, both women and men should take Impryl for at least 90 days prior to natural conception or an ART procedure, and then until a pregnancy is achieved. This duration is based on the duration of folliculogenesis/ovulation (egg production) and spermatogenesis (sperm production). However, if it is not possible to take Impryl for 90 days or longer, any shorter duration will be of benefit. The assumption may be continued during pregnancy and lactation.
Those willing to control their homocysteine should be aware that the feeding effects, as well those on homocysteine, will terminate days to weeks after withdrawal and homocysteine may raise back to pre-treatment values.
We recommend all of our customers consult with their healthcare provider to ensure they are receiving the proper nutritional support.
How should IMPRYL® be stored?
Impryl should be stored in its original packaging at room temperature out of the reach of children. It should be protected from direct sunlight, as well as extreme oscillations in temperature and/or humidity.
How does IMPRYL® works?
Impryl ingredients were carefully selected because each plays an important role in a process in your body called One Carbon Metabolism (OCM). OCM uses the micronutrients provided by Impryl to power five biological processes – homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression – each important for sperm health and egg quality, fertilization, and the growth and development of the baby.
What is One Carbon Metabolism (OCM)?
OCM is a network of biochemical cycles (folate and methionine) and biochemical pathways (betaine and transsulfuration) that involve the transfer of a single carbon molecule in the form of a methyl, methylene or formyl group from one molecule to another. OCM has been shown to be critical for the reproductive health of women and men.
Why is One Carbon Metabolism (OCM) important?
OCM is important because it functionally connects the dietary intake of micronutrients with critical biological processes, including homocysteine recycling, DNA/RNA synthesis, cellular energy production, natural antioxidant activity and gene expression. Learn about how Impryl works. Disruption of OCM by diet, environmental exposure or genetic variations is associated with multiple human reproductive health problems, including reduced sperm health and egg quality, infertility and miscarriage, as well as birth defects, including spina bifida.
What is a methyl group?
A methyl group is a single carbon atom bonded with three hydrogen atoms. The methionine pathway of One Carbon Metabolism (OCM) produces S-adenosylmethionine (SAMe), the universal activated methyl donor in the human body. Methyl groups can be dynamically transferred to and from biological macromolecules such as DNA, RNA and proteins in a process called methylation to influence structure and function.
What is homocysteine (HCY)?
Homocysteine is a naturally occurring, non-proteinogenic amino acid that accumulates when One Carbon Metabolism (OCM) is suboptimal. Elevated levels of homocysteine are a risk factor for multiple human reproductive health issues, including both male and female infertility, preeclampsia, miscarriage, and birth defects like spina bifida. Homocysteine is recycled to methionine through methylation by the methionine and betaine pathway of OCM, or converted to cystathione by the transsulfuration pathway of OCM.
What is glutathione?
Glutathione (GSH) is the main antioxidant in the human body. It diffuses everywhere and continuously re-charges with antioxidant power all the other physiologic antioxidants. Important, GSH is not a dietary substance and is not provided by the diet neither can be assumed as a supplement. Glutathione is synthesized by the transsulfuration pathway of One Carbon Metabolism (OCM) using homocysteine/cysteine as the main substrate.
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What is the importance of 5-MTHF and Methylcobalamin?
5-MTHF and methylcobalamin are methyl donors necessary for the re-methylation of homocysteine to methionine. Carriers of defective genetic variants of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), are weak producers of, respectively, 5-MTHF and methylcobalamin and may be at risk of shortage of these substances.
What is the importance of Betaine?
Betaine (also called trimethyl-glycine) is produced in the body from choline. While choline does play other roles in the body, the production of betaine is essential because it serves as a methyl donor in the methionine pathway of OCM to promote re-methylation of homocysteine to methionine.
What is the importance of L-Cystine?
L-cystine is made of two cysteines and is the soluble and circulating form of cysteine. Into the cells, L-cystine is transformd into 2 cysteines on demand. Cysteine is the main substrate for the synthesis of the main physiologic antioxidants: glutathione (GSH) and of hydrogen sulfide (H2S).
What is the importance of Vitamin B2, B3 and B6?
Vitamin B2, B3 and B6 are all necessary cofactors for the critical enzymes in One Carbon Metabolism (OCM).
What is the importance of zinc?
Zinc is a metal that binds certain enzymes and essential for their activity. Only zinc bound to dietary proteins or to other carrier molecules can be adsorbed can, in Impryl the carrier is bisglycinate. Rather, elemental zinc as contained by many supplements is completely lost with the feces.
All the 3 main enzymes eliminating homocysteine to form methionine or cysteine are zinc-dependent and the OCM cannot work properly if any shortage of zinc is in place. Thus, it is very important for the effects of Impryl.
However, zinc competes with other bivalent metals, mainly copper and magnesium, for transport into the cells. Therefore, excessive supplementation of zinc leading to high concentration, may reduce the transport and availability of other cations with negative consequences. This is the reason why, a few years ago, Parthenogen decreased the amount of zinc per tablet from 15 to 10 mg. Always updated with any new findings, we deserve further reductions of zinc amounts should the data advice so.
What is the consequence of genetic variants?
Genetic variants are genetic traits that are different from the most common ones (called wild type) but occurring with high frequency (> 10%) and are therefore physiologic. In other words, they are not diseases, they are just “variants” from normal. In some cases the variant generates an enzyme with a decreased activity, likely because it was (and is) and advantage in certain situations. In the case of MTHFR variants, resulting in decreased output of 5MTHF, one may argue that it was an advantage against malaria (shorter half life of red cells) and is an advantage against cancers (that are usually folate dependent). The same may apply to the majority of genetic variants, the larger their frequency, the more the side benefits they bring.
However, it may happen that multiple genetic variants on the same pathway converge on the same subject generating a critical assembly. In these cases any increased demand or toxic load may generate a metabolic collapse. Such collapse is predicted to occur at time of increased demand, which in the case of the one carbon metabolism is at time to reproduce.
How is IMPRYL® manufactured?
Impryl is manufactured in the Italy using domestic and imported ingredients in a facility that is certified to current good manufacturing practice (cGMP) standards. Following manufacturing, each lot of Impryl is laboratory tested and released for sale only after demonstrating compliance with product-specific acceptance criteria.
Is IMPRYL® Gluten-Free?
Yes, Impryl is gluten-free.
Is IMPRYL® Lactose-Free?
Yes, Impryl is lactose-free.
Is IMPRYL® suitable for use by vegetarians and vegans?
Yes, Impryl can be used by individuals who consciously choose to avoid products of animal origin. In addition, none of the ingredients in Impryl are produced using genetically modified organisms (GMO).
Does IMPRYL® contain any artificial colors or flavors?
No, Impryl does not contain any artificial colors or flavors.
Does IMPRYL® have any side effects?
Impryl contains ingredients that are both present in the food supply and naturally occur in the body, at concentrations that approximate the recommended daily allowances. Nevertheless, adults consuming Impryl should consult a physician if pregnant or nursing, taking prescription medication, or have a medical condition, and Impryl should never be consumed by individuals with known allergies to any ingredients in the product.
Can IMPRYL® packaging be recycled?
Impryl packaging are composed by a carton box (PAP21) and 2 blisters (C/PVC). Please check the regulations of your country.
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Anonymous (Verified Buyer) –
Very effective !!!
Silviu (Verified Buyer) –
Very good
Muntean (Verified Buyer) –
Very good services
raul ionica (Verified Buyer) –
The product itself is very good and helpful. However, when I ordered a second time (2 boxes), I was disappointed with the delivery. Even though I paid for express shipping, which should have arrived in 1–2 business days, I am still waiting after 8 days.
Parthenogen Europe (store manager) –
Dear Raul, we appreciate your comments and we want to thank you for your kind feedback. Every shipment we made is express, supposed to arrive in few days. However, our logistics partners may occasionally delay shipments due to high demand. These events are beyond our control, and we have no control over them. Thank you again for your valuable feedback; we always strive to provide a safe, fast, and responsive service. For any urgency you can always contact us, we are here to help!
The Parthenogen Europe team
Tudorel Obreja (Verified Buyer) –
Dezamăgitor!am plătit extra pentru a imi ajunge comanda cum mi-au spus in 1-2 zile lucrătoare,mi-au luat banii si am așteptat aproape doua săptămâni comanda,daca erau serioși măcar ce am dat in plus mii transfera inapoi si isi cereau scuze
Parthenogen Europe (store manager) –
Dear Tudorel, we appreciate your comments and we want to thank you for your kind feedback. Every shipment we made is express, supposed to arrive in few days. However, our logistics partners may occasionally delay shipments due to high demand. These events are beyond our control, and we have no control over them. Thank you again for your valuable feedback; we always strive to provide a safe, fast, and responsive service. For any urgency you can always contact us, we are here to help!
The Parthenogen Europe team
Comanita N. (Verified Buyer) –
Verry fast the order
Pintilie Gianina (Verified Buyer) –
Foarte bun
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The order arrived very quickly. I really recommend this website
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It s the best
Toader Catalin (Verified Buyer) –
.
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Anonymous (Verified Buyer) –
Very good
Anonymous (Verified Buyer) –
Everything was ok.
Pintilie Gianina (Verified Buyer) –
It.s good
Aliona Hriscu (Verified Buyer) –
.
Arsenescu P. (Verified Buyer) –
Very good for organism.
Alexandru (Verified Buyer) –
Foarte ok
Anonymous (Verified Buyer) –
Foarte ok, încă continui tratamentul
Vlad Grigore (Verified Buyer) –
Very good
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Ok.
Adrian A. (Verified Buyer) –
If IT will be possible to be more cheper. IT will be great
Marius Stănilă (Verified Buyer) –
Mulțumesc pentru ajutor . Cel mai corect preț de pe piață . Cel mai rapid colet sosit vreodată . Vă multumesc .
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Super, very fast
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Very content
VALENTIN PREOTEASA (Verified Buyer) –
–
Anonymous (Verified Buyer) –
The shippment was very fast.
Elvin A. (Verified Buyer) –
Delivery was very fast
Lucian D. (Verified Buyer) –
The product arrived in safe
Andreea Celmare (Verified Buyer) –
Ok
Maria Iuliana Chirica (Verified Buyer) –
Good supplement!
Ramona Tunaru (Verified Buyer) –
Ramona Tunaru
Anonymous (Verified Buyer) –
.
Anonymous (Verified Buyer) –
Great!
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Verry good
Ungureanu Madalina (Verified Buyer) –
Good✔️
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very fast delivery
Anonymous (Verified Buyer) –
Livrarea a ajuns super repede în 2 zile.
Anonymous (Verified Buyer) –
Like
Marius (Verified Buyer) –
The order came very quickly
Ionut C. (Verified Buyer) –
very good price
Ramona Son (Verified Buyer) –
Excellent
Florin N. (Verified Buyer) –
Impryl is a very good supplement, but at last order the web page for ordering it did not functioned for half a day. So it happened last Thursday and I could pay it online, only on the evening of Thursday was possible. So that delivery was not possible anymore for Friday next day as it was at my first order. It was delivered Monday. Hope that they solved the problem.
Francois C. (Verified Buyer) –
Shipment on time
Dan Marinescu (Verified Buyer) –
Excellent
Patrice CLEMENT (Verified Buyer) –
TOP SERVICE
Olivia (Verified Buyer) –
Flawless ordering process, quick delivery. The benefits of the meds are still to take effect, as I started taking them recently.
Anonymous (Verified Buyer) –
The product arrived very fast and the order was fine.
Dumitrascu A. (Verified Buyer) –
–
Zoran Fischer (Verified Buyer) –
Ok
Dumitru D. (Verified Buyer) –
Good
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Very good!
Zornitsa Belmustakova (Verified Buyer) –
I feel very good. I am ordering for the second time. I believe that pills will help me.
Ion Stefan (Verified Buyer) –
Delivery was prompt, and now we wait to see the effect of medicine to make a full review!!
Thanks!
Daniela S. (Verified Buyer) –
Foarte mulțumită a ajuns comanda in 3zile
Ramona Son (Verified Buyer) –
Fast delivery
Robert V. (Verified Buyer) –
The best choice for the fulfillment of the greatest desire: the child.
Anonymous (Verified Buyer) –
Good
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Very good
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Excellent service!
Anonymous (Verified Buyer) –
The order arrived very fast.
Anonymous (Verified Buyer) –
Thank you very much
roxana c. (Verified Buyer) –
Consegna molto veloce in Romania 2 giorni ! Rimane da vedere il risultato!
Anonymous (Verified Buyer) –
Bien
STOICA AUREL NICOLAE (Verified Buyer) –
Foarte serioși. Pachetul a ajuns la mine foarte repede.
ADRIAN T. (Verified Buyer) –
2 workday delivery for Bucharest Romania
Dumitrascu A. (Verified Buyer) –
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Alina D. (Verified Buyer) –
very prompt service! I would highly recommend the product and service!
VALENTIN (Verified Buyer) –
Produsul este cel comandat.Livrare prompta.
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Very fast
Anonymous (Verified Buyer) –
The shipment was very fast and the product was fine.
Rosu Ionut (Verified Buyer) –
It
Urda Andra (Verified Buyer) –
Ok
Anonymous (Verified Buyer) –
We are taking it at the recommendation of our doctor, in order to improve our outcome for IVF.
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Fast delivery, very good product
Plangu Alina (Verified Buyer) –
Good
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Ok
Trofin Edvin Persian (Verified Buyer) –
L-am comandat din România. A ajuns foarte repede. Mulțumesc pentru promptitudine și seriozitate.
Ruxandra (Verified Buyer) –
very fast delivery, kind people that guide you at need
Alexandra (Verified Buyer) –
Very good
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Foarte mulțumit livrare super rapida
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Ok
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very good product
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Excelent quality
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Foarte eficiente
Alexandru Cristian Leordeanu (Verified Buyer) –
Great
Anonymous (Verified Buyer) –
The delivery was fast, the payment…everything ok. But the packaging of the products leaves a lot to be desired. Please improve the packaging, especially for long distances, so that the products arrive properly. I received them crushed. Thank you!
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Very fast delivery
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It really works
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Very easy to order. Very very fast delivery. Great experience
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very good
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super speedy delivery, big like
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Mulțumit !
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Foarte promti
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Fast delivery
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Product delivered very quickly
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very good product
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Livrare rapida si in siguranta.
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A very serios company,deliveries are made one day after another,thank you!!
Simion Marian (Verified Buyer) –
Good
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Super
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Perfect!
Rosca Gina (Verified Buyer) –
Foarte multumita ,coletul ajunge repede in stare intacta . Felicitări!
ALEXANDRA C. (Verified Buyer) –
Fast delivey
Adrian A. (Verified Buyer) –
Very fast delivery. Next dat from order
Anonymous (Verified Buyer) –
Comanda a venit repede…revin cu detalii
Anonymous (Verified Buyer) –
okkk
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A ajuns foarte bine si repede in Romania, voi reveni pentru o alta comanda.
O zi buna!
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The Best!
Anonymous (Verified Buyer) –
The order was delivered fast. Pick-up point, unfortunately, it isn’t available
Nedelcu Ionut Marius (Verified Buyer) –
Foarte bun
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Excellently
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The package arrived very quick,very well secure and very good.
I recommend
Anonymous (Verified Buyer) –
I received the products very quickly. This is the second batch of products that I order and I am waiting for results.
Anonymous (Verified Buyer) –
okkk
Ionut Gabriel Olteanu (Verified Buyer) –
La recomandarea medicului, am achizitionat impryl si am folosit timp de 3 luni, si a dat rezultate foarte bune la problema pe care am avut-o. Un produs excelent.
Anonymous (Verified Buyer) –
perfect
Girba C. (Verified Buyer) –
Very good
Mirela T. (Verified Buyer) –
Livrarea este foarte rapida
Musuroi Alex Stefan (Verified Buyer) –
Great! Arrived in 2 days to Romania
Badea M. (Verified Buyer) –
Ok
Serlau A. (Verified Buyer) –
Recomand !!!
Gules Veronica (Verified Buyer) –
Sunt foarte mulțumită de comanda,de rapiditatea livrarii
Anonymous (Verified Buyer) –
Livrare promptă! Totul ok, acum ..asteptam sa vedem si rezultatele
Anonymous (Verified Buyer) –
–
Mihai Grama (Verified Buyer) –
Super , sper sa-mi fie de folos !
Stanescu A. (Verified Buyer) –
Best
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Foarte promti
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Fast shipment, everything was ok.
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Very fast delivery to Romania.
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A venit f repede
Mocanu Silviu stefan (Verified Buyer) –
Very good company
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Very good!
Mioara R. (Verified Buyer) –
my husband evolved from 0% to 50% progressive spermatozoa in two and a half months.
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IT was delivered very quick!
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The delivery is very good !
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It was delivered very quickly.
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Fast delivery
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Very promt delivery
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Expediere foarte rapida!
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Great experience. Fast delivery
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a good product
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I hope it will have the expected effect.
Marius M. (Verified Buyer) –
Produsul vine in 2 zile, IT-RO
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Super reiese au sosit
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Radu (Verified Buyer) –
Everithing was ok!
Petria Ionuț Gabriel (Verified Buyer) –
My order is not arive not even now ,that is not ok !
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Fast delivery, thank you
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arrived fast
MOULAIN (Verified Buyer) –
Livraison très rapide. Nous n’avons pa encore assez de recule par rapport à une amélioration.
Alexandra M. (Verified Buyer) –
very happy with the delivery, the product still needs to be tested 🙂
Andreea Motica (Verified Buyer) –
.
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–
Silvestru Gabriel (Verified Buyer) –
Gabriel Silvestru
Ioana (Verified Buyer) –
Really fast response and delivery. Great product.
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Anonymous (Verified Buyer) –
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Anonymous (Verified Buyer) –